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Title Microfluidics for assessing the behaviour of deformable biological objects / Joana Fidalgo.
Name Fidalgo, Joana. .
Abstract Biological fluids, composed of polymeric solutions or suspensions of deformable particles, commonly present complex rheological behaviour. It is well known that particle-fluid interactions at the microscale dictate the macroscopic flow behaviour of these fluids, however the exact link in numerous situations is still missing. Recently, microfluidic techniques have been widely employed to study the dynamics of microscopic particles under flow.
Abstract Even though such techniques present a range of advantages, including the precise control of the flow conditions, as well as the consumption of a small amount of sample, the design of the microfluidic geometries still mostly relies on a trial-and-error approach. In this thesis, we experimentally test a set of microfluidic geometries, the design of which was previously optimised based on theoretical considerations or by means of numerical simulations in order to achieve specific flow conditions.
Abstract In addition, we have used complex observation techniques to study the dynamics of solutions and suspensions under flow, identifying microscopic dynamics as well as the major limitations of the microfluidic devices. Biological fluids such as solutions of DNA molecules and red blood cells suspensions were investigated in shear-dominated and extension-dominated flows and the performance of the optimised flow geometries for the study of such biological fluids was demonstrated.
Publication date 2019.
Name Oliveira, Monica, degree supervisor.
Name Lindner, Anke, degree supervisor.
Name University of Strathclyde. Department of Mechanical and Aerospace Engineering.
Name University of Strathclyde. Department of Mechanical & Aerospace Engineering. James Weir Fluids Laboratory.
Thesis note Thesis Ph. D. University of Strathclyde 2019 T15256

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